The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 16, 1999
Filed:
Oct. 27, 1994
Applicant:
Inventors:
Giandomenico Russo, Rome, IT;
Carlo M Croce, Philadelphia, PA (US);
Assignees:
Thomas Jefferson University, Philadelphia, PA (US);
Raggio-Italgene S.p.A., Rome, IT;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12P / ; C07H / ; C12N / ; C12N / ;
U.S. Cl.
CPC ...
435 691 ; 435 701 ; 435 711 ; 435 911 ; 435 914 ; 4353201 ; 536 231 ; 536 241 ;
Abstract
The present invention relates to nucleotide sequences of TCL-1 genes and amino acid sequences of their encoded proteins, as well as derivatives and analogs thereof, and antibodies thereto. The TCL-1 gene sequence is preferentially expressed early in T and B lymphocyte differentiation. The present invention further relates to the use of TCL-1 genes and their encoded proteins as diagnostic and therapeutic reagents for the detection and treatment of disease states associated with chromosomal abnormalities.