The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 16, 1999
Filed:
Aug. 27, 1997
Mark A Findeis, Cambridge, MA (US);
Malcolm L Gefter, Lincoln, MA (US);
Gary Musso, Hopkinton, MA (US);
Ethan R Signer, Cambridge, MA (US);
James Wakefield, Brookline, MA (US);
Susan Molineaux, Brookline, MA (US);
Joseph Chin, Salem, MA (US);
Jung-Ja Lee, Wayland, MA (US);
Michael Kelley, Arlington, MA (US);
Sonja Komar-Panicucci, Bedford, MA (US);
Christopher C Arico-Muendel, Watertown, MA (US);
Kathryn Phillips, Marlborough, MA (US);
Neil J Hayward, North Grafton, MA (US);
Praecis Pharmaceuticals, Inc., Cambridge, MA (US);
Abstract
Compounds that modulate natural .beta. amyloid peptide aggregation are provided. The modulators of the invention comprise a peptide, preferably based on a .beta. amyloid peptide, that is comprised entirely of D-amino acids. Preferably, the peptide comprises 3-5 D-amino acid residues and includes at least two D-amino acid residues independently selected from the group consisting of D-leucine, D-phenylalanine and D-valine. In a particularly preferred embodiment, the peptide is a retro-inverso isomer of a .beta. amyloid peptide, preferably a retro-inverso isomer of A.beta..sub.17-21. In certain embodiments, the peptide is modified at the amino-terminus, the carboxy-terminus, or both. Preferred amino-terminal modifying groups include cyclic, heterocyclic, polycyclic and branched alkyl groups. Preferred carboxy-terminal modifying groups include an amide group, an alkyl amide group, an aryl amide group or a hydroxy group. Pharmaceutical compositions comprising the compounds of the invention, and diagnostic and treatment methods for amyloidogenic diseases using the compounds of the invention, are also disclosed.