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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 5981726 B1

PDFFull Text
Date of Patent:
Nov. 09, 1999

Filed:

Oct. 28, 1994

Chimeric and mutationally stabilized tumor-specific b1, b3 and b5

Applicant:
Inventors:

Ira Pastan, Potomac, MD (US);

Itai Benhar, Rockville, MD (US);

Assignee:

The United States of America as represented by the Department of Health, , US;

Attorney:

Townsend and Townsend and Crew LLP

Primary Examiner:

Paula K Hutzell

Assistant Examiner:

Julie E Burke

Int. Cl.
CPC ...
A61K / ; C07M / ;
U.S. Cl.
CPC ...
536 2353 ; 5303873 ; 5303877 ; 5303897 ; 5303917 ; 4241331 ; 4241351 ; 4241381 ; 4241551 ; 4241741 ; 4241811 ; 4241831 ; 435328 ; 435344 ; 435 696 ; 435 697 ; 435 911 ; 536 234 ;
Abstract

This invention provides for recombinant single chain antibodies capable of specifically binding to a Lewis.sup.Y -related carbohydrate antigen and fusion proteins comprising these antibodies. More particularly, the invention provides for single chain Fv regions of the monoclonal antibodies B1 and B5. The invention also provides for a number of stabilizing mutations of the Lewis.sup.Y -binding monoclonal antibody B3. In addition, the invention provides for methods of detecting cells bearing a Lewis.sup.Y antigen in a patient and for methods of killing or inhibiting the growth of cells bearing a Lewis.sup.Y antigen in a patient.

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Pastan, Ira. (1999). Chimeric and mutationally stabilized tumor-specific b1, b3 and b5 (U.S. Patent No. 5981726). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/5981726

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