The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 09, 1999
Filed:
Nov. 08, 1996
Applicant:
Inventor:
Benjamin Weiss, Wynnewood, PA (US);
Assignee:
Allegheny University of the Health Sciences, Philadelphia, PA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N / ;
U.S. Cl.
CPC ...
435375 ; 435 911 ; 4353201 ; 435377 ; 435455 ; 424450 ; 514 44 ; 536 245 ; 536 231 ; 536 233 ; 536 2331 ; 536 2333 ;
Abstract
Constructs encoding calmodulin antisense molecules are disclosed. These constructs may be used to advantage to inhibit proliferation of malignant cells. The invention further comprises monoclonal antibody studded liposomes to facilitate cell-type specific delivery of the antisense calmodulin constructs. To enhance cell-type specific expression of calmodulin antisense sequences, cell-type specific promoters are employed to drive expression of the antisense molecules in targeted tissues.