The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 02, 1999
Filed:
Apr. 14, 1995
Applicant:
Inventors:
J David Brook, West Bridgford, GB;
David E Housman, Newton, MA (US);
Duncan J Shaw, Banchory, GB;
Helen G Harley, Rhiwbina, GB;
Keith J Johnson, Glasgow, GB;
Assignees:
Massachusetts Institute of Technology, Cambridge, MA (US);
University of Wales College of Medicine, Cardiff, GB;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07H / ; C07H / ; C12P / ; C12Q / ;
U.S. Cl.
CPC ...
536 232 ; 536 243 ; 536 2433 ; 536 235 ; 435-6 ; 435 912 ; 935-6 ; 935-8 ; 935-9 ; 935 78 ;
Abstract
A nucleotide sequence, specifically a CTG triplet repeat, is shown to be expanded in individuals affected with myotonic dystrophy and can be identified in a sample obtained from an individual. Individuals in whom the CTG triplet repeat is present in normal copy number are likely to be minimally affected and individuals in whom the CTG triplet repeat occurs in abnormally high copy number are likely to be more severely affected.