The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 02, 1999
Filed:
Jun. 07, 1995
Applicant:
Inventors:
Peter S Mezes, Oldlyme, CT (US);
Ruth A Richard, Midland, MI (US);
Kimberly S Johnson, New London, CT (US);
Assignee:
The Dow Chemical Company, Midland, MI (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N / ; C07K / ;
U.S. Cl.
CPC ...
4351722 ; 435328 ; 435344 ; 5303873 ; 5303877 ; 5303888 ; 4241331 ; 4241381 ;
Abstract
This invention concerns a subset of composite Hum4 V.sub.L, V.sub.H antibodies with high affinities to a high molecular weight, tumor-associated sialylated glycoprotein antigen (TAG-72) of human origin. These antibodies have variable regions with (1) V.sub.L segments derived from the human subgroup IV germline gene, and (2) a V.sub.H segment which is capable of combining with the V.sub.L to form a three dimensional structure having the ability to bind TAG-72. In vivo methods of treatment and diagnostic assay using these composite antibodies is also disclosed.