The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 02, 1999

Filed:

Apr. 07, 1997
Applicant:
Inventors:

John Lee Pace, Germantown, MD (US);

Richard Ives Walker, Gaithersburg, MD (US);

Steven Michael Frey, Bothell, WA (US);

Assignee:

Antex Biologics Inc., Gaithersburg, MD (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A01N / ; A61K / ; C12N / ; C12Q / ;
U.S. Cl.
CPC ...
424 934 ; 4242821 ; 435 29 ; 435 30 ; 435 34 ; 435 38 ; 435822 ; 435-71 ; 4352521 ;
Abstract

Methods using in vitro processes are disclosed for inducing or enhancing expression of enteric bacterial antigens or virulence factors. The methods, therefore, produce antigenically enhanced enteric bacteria. Also disclosed are methods for using the antigenically enhanced bacteria, as well as vaccines containing the enteric bacteria. Specifically, a whole enteric bacteria or components thereof are provided by Campylobacter species. In addition to this species there are other enteric bacteria, such as Yersinia spp., Bacteroides spp., Klebsiella spp., Gastrospirillum spp., Enterobacter spp., Salmonella spp., Aeromonas spp., Vibrio spp., Clostridium spp., Enterococcus spp., and Escherichia coli, which are useful for inducing or enhancing expression of enteric bacterial antigens and/or virulence factors.


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