The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 26, 1999
Filed:
Jul. 26, 1996
Applicant:
Inventors:
Paul J Hippenmeyer, St. Louis, MO (US);
Anne M Rankin, Ballwin, MO (US);
Verne A Luckow, Chesterfield, MO (US);
Assignee:
G. D. Searle & Co., Chicago, IL (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N / ; C12N / ; A01N / ; A61K / ;
U.S. Cl.
CPC ...
4351723 ; 424 932 ; 4242301 ; 4242311 ; 4242291 ; 435236 ; 435325 ;
Abstract
A vaccine is described which comprises an assembly-deficient herpesvirus. The mutant herpesvirus is capable of infecting and undergoing DNA replication in the cells of a susceptible mammal, but is defective in capsid assembly and formation of mature virion particles. The assembly-deficient herpesvirus is avirulent and capable of generating a protective immune response in a vaccinated mammal.