The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 19, 1999
Filed:
Jun. 26, 1998
Ki-Joon Shon, Shaker Heights, OH (US);
William R Gray, Salt Lake City, UT (US);
John Dykert, Vista, CA (US);
Doju Yoshikami, Salt Lake City, UT (US);
Maren Watkins, Salt Lake City, UT (US);
David R Hillyard, Salt Lake City, UT (US);
Jean E Rivier, La Jolla, CA (US);
Baldomero M Olivera, Salt Lake City, UT (US);
The Salk Institute for Biological Studies, La Jolla, CA (US);
University of Utah Research Foundation, Salt Lake City, UT (US);
Abstract
Substantially pure conotoxin peptides are provided which inhibit synaptic transmissions at the neuromuscular junctions and which are useful both in vivo and in assays because they specifically target particular skeletal nAChRs to the exclusion of neuronal nAChRs. The peptides are of such length that they can be made by chemical synthesis, and the preferred peptides have formula: H-His-4Hyp-4Hyp-Cys-Cys-Leu-Tyr-Gly-Lys-Cys-Arg-Arg-Tyr-4Hyp-Gly-Cys-Ser-S er-Ala-Ser-Cys-Cys-Gln-Xaa.sub.24 -NH.sub.2 wherein Xaa.sub.24 is Arg or Gly.