The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 19, 1999
Filed:
Oct. 05, 1998
Applicant:
Inventors:
Bruce E Maryanoff, Forest Grove, PA (US);
David McComsey, Warminster, PA (US);
James J McNally, Souderton, PA (US);
Samuel O Nortey, LaMott, PA (US);
Allen B Reitz, Lansdale, PA (US);
Assignee:
Ortho-McNeil Pharmaceutical, Inc., Raritaon, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; C07D / ;
U.S. Cl.
CPC ...
514293 ; 546 82 ;
Abstract
This invention relates to a series of substituted 3-oxo-pyrrolo[1,2-a]imidazopyridine derivatives of the formula 1 ##STR1## where X.sub.1 -X.sub.4, R.sub.1, R.sub.2 and Ar are defined herein. In addition the invention relates to pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention are ligands for the benzodiazepine site on the GABA-A receptor and display anxiolytic and anticonvulsant activity in animal models.