The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 19, 1999
Filed:
Aug. 04, 1995
Sudhir Agrawal, Shrewsbury, MA (US);
Jamal Temsamani, Worcester, MA (US);
Qiuyan Zhao, Worcester, MA (US);
Hybridon, Inc., Milford, MA (US);
Abstract
The present invention provides a method of reducing the immunostimulatory effects of certain phosphorothioate oligonucleotides used to treat pathogen-mediated disease states and other medical conditions. Immunostimulatory effects of phosphorothioate oligonucleotides are reduced in accordance with the method of the invention by modifying at least one chemical structure within the phosphorothioate oligonucleotide to produce an immunostimulatory response-reducing phosphorothioate oligonucleotide, which is then administered to a mammal afflicted with the disease or condition being treated. The immune response of the mammal is also monitored in the method of the invention.