The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 05, 1999
Filed:
Feb. 26, 1996
Applicant:
Inventors:
Radhakrishnan P Iyer, Shrewsbury, MA (US);
Theresa Devlin, Jamaica Plain, MA (US);
Ivan Habus, Shrewsbury, MA (US);
Dong Yu, Shrewsbury, MA (US);
Sudhir Agrawal, Shrewsbury, MA (US);
Assignee:
Hybridon, Inc., Milford, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H / ;
U.S. Cl.
CPC ...
536 2534 ; 536 253 ; 536 2531 ; 536 2533 ; 536 231 ;
Abstract
The invention provides new reagents and an improved process for synthesizing oligonucleotides that contain methylphosphonate internucleoside linkages. The reagents and process utilize a nucleoside base protecting group that is stable under oligonucleotide synthesis conditions, but which can be removed under more mild conditions than existing protecting groups.