The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 28, 1999
Filed:
Oct. 22, 1997
Applicant:
Inventors:
Philip John Burke, London, GB;
Robert Ian Dowell, Congleton, GB;
Anthony Brian Mauger, Kensington, MD (US);
Caroline Joy Springer, London, GB;
Assignees:
Zeneca Limited, London, GB;
Cancer Research Campaign Technology Limited, London, GB;
Primary Examiner:
Int. Cl.
CPC ...
A01N / ;
U.S. Cl.
CPC ...
514476 ; 560134 ; 560135 ; 560136 ; 560137 ; 564 15 ; 564162 ; 564180 ;
Abstract
Prodrugs, of generic formula I, are disclosed for use in antibody directed enzyme prodrug therapy (ADEPT). The prodrugs are substrates for carboxypeptidase G2 (CPG2) and yield more active cytotoxic drugs than known products of CPG2 catalyzed reactions.