The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 28, 1999
Filed:
Dec. 24, 1997
Elliott S Klein, Marina del Rey, CA (US);
Alan T Johnson, Rancho Santa Margarita, CA (US);
Andrew M Standeven, Ventura, CA (US);
Richard L Beard, Newport Beach, CA (US);
Samuel J Gillett, Albany, CA (US);
Tien T Duong, Irvine, CA (US);
Sunil Nagpal, Lake Forest, CA (US);
Vidyasagar Vuligonda, Irvine, CA (US);
Min Teng, San Diego, CA (US);
Roshantha A Chandraratna, Mission Viejo, CA (US);
Allergan Sales, Inc., Irvine, CA (US);
Abstract
2,2-Dialkyl-4-aryl-substituted benzopyran and benzothiopyran derivatives of the formula ##STR1## where the symbols have the meaning described in the specification, have retinoid negative hormone and/or antagonist-like biological activities. The invented RAR antagonists can be administered to mammals, including humans, for the purpose of preventing or diminishing action of RAR agonists on the bound receptor sites. Specifically, the RAR agonists are administered or coadministered with retinoid drugs to prevent or ameliorate toxicity or side effects caused by retinoids or vitamin A or vitamin A precursors. The retinoid negative hormones can be used to potentiate the activities of other retinoids and nuclear receptor agonists.