The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 28, 1999

Filed:

Apr. 08, 1996
Applicant:
Inventors:

Stefan Stang.hl, Gorvik, SE;

Per-ANG.ke Nygren, Pilotgatan, SE;

Marianne Hansson, Bl.ang.sutyagen, SE;

Mathias Uhlen, Kvarnbogatan, SE;

Thien Ngoc Nguyen, St. Julien, FR;

Assignee:

Pierre Fabre Medicament, Boulogne, FR;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N / ;
U.S. Cl.
CPC ...
435 697 ; 435 693 ; 435 691 ; 435 698 ; 435-71 ; 4351721 ; 4352523 ; 4352534 ; 435882 ; 435883 ; 4241921 ; 536 235 ;
Abstract

Tripartite recombinant DNA encoding fusion proteins which comprise three sequences, i.e., a signal peptide which is operable in a Gram positive bacterium, an immunogenic polypeptide linked thereto which is not normally expressed in a Gram positive bacterium, and a cell wall spanning and a membrane anchoring sequence, as well as their use in Gram positive bacteria to express the resultant fusion protein on their surface are described. The preferred cell wall spanning and anchoring polypeptides include Staphylococcus protein A and Streptococcus protein G.


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