The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 21, 1999
Filed:
Jun. 07, 1995
Richard E Moore, Honolulu, HI (US);
Charles D Smith, Feasterville, PA (US);
Gregory M Patterson, Honolulu, HI (US);
Susan L Mooberry, Honolulu, HI (US);
Thomas H Corbett, Grosse Point, MI (US);
Frederick A Valeriote, Shelby Township, MI (US);
Trimurtulu Golakoti, Honolulu, HI (US);
The University of Hawaii, Honolulu, HI (US);
Wayne State University, Detroit, MI (US);
Abstract
A cryptophycin compound is provided having the structure: ##STR1## Further provided are methods for producing novel cryptophycins from the Nostoc sp. of blue-green algae (cyanobacteria). Pharmaceutical compositions comprising novel cryptophycins are also provided, as are methods for using cryptophycins to inhibit the proliferation of hyperproliferative cells. Further provided are methods for using cryptophycins to inhibit the proliferation of hyperproliferative cells with drug resistant phenotypes, and to treat pathological conditions, such as neoplasia.