The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 14, 1999
Filed:
Jul. 21, 1993
Applicant:
Inventors:
Thomas Joseph Commons, Wayne, PA (US);
Donald Peter Strike, St. Davids, PA (US);
Christa Marie LaClair, Newtown, PA (US);
Assignee:
American Home Products Corporation, Madison, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; C07D / ;
U.S. Cl.
CPC ...
514327 ; 514210 ; 514211 ; 514212 ; 5142275 ; 5142278 ; 5142282 ; 5142312 ; 5142378 ; 514255 ; 514256 ; 514269 ; 514278 ; 514307 ; 514309 ; 514311 ; 514312 ; 514313 ; 514316 ; 514317 ; 514318 ; 514319 ; 514320 ; 514321 ; 514322 ; 514323 ; 514328 ; 514330 ; 514365 ; 514366 ; 514367 ; 514372 ; 514373 ; 514374 ; 514375 ; 514378 ; 514379 ; 514396 ; 514397 ; 514398 ; 540466 ; 540480 ; 540481 ; 540482 ; 540543 ; 540604 ; 544 59 ; 544 60 ; 544 61 ; 544 62 ; 544111 ; 544298 ; 544315 ; 544316 ; 544319 ; 544405 ; 546 16 ; 546141 ; 546153 ; 546157 ; 546186 ; 546187 ; 546188 ; 546208 ; 546209 ; 546210 ; 546212 ; 546214 ; 548146 ; 548152 ; 548182 ; 548206 ; 548215 ; 548225 ; 548240 ; 548241 ; 548243 ; 5482624 ; 5482642 ; 5482641 ; 548950 ; 548952 ;
Abstract
Inhibition of the enzymes cholesterol ester hydrolase (CEH) and/or acyl coenzyme A: cholesterol acyltransferase (ACAT) results in the inhibition of the esterification of cholesterol and are therefore implicated in the inhibition of absorption of cholesterol and thus can lower serum cholesterol levels. Compounds of the formula: ##STR1## where Z is ##STR2## or --Ar.sup.1 --(CR.dbd.CR).sub.1-3 --Ar.sup.2, --AR.sup.1 --NR.sup.7 --AR.sup.2 and A is a linking group inhibit the enzymes CEH and/or ACAT (in vitro) and inhibit absorption of cholesterol.