The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 07, 1999
Filed:
Feb. 14, 1996
Applicant:
Inventors:
Nicholas M Dean, Encinitas, CA (US);
Pierre Martin, Rheinfelden, CH;
Karl-Heinz Altmann, Reinach, CH;
Assignees:
ISIS Pharmaceuticals, Inc., Carlsbad, CA (US);
Ciba-Geigy AG, Basel, CH;
Primary Examiner:
Int. Cl.
CPC ...
C07H / ;
U.S. Cl.
CPC ...
536 235 ; 514 44 ; 536 221 ; 536 231 ; 536 241 ; 536 251 ; 536 252 ; 435 911 ;
Abstract
Compositions and methods are provided for modulating the expression of protein kinase C. Oligonucleotides are provided which are targeted to nucleic acids encoding PKC. The oligonucleotides contain a methoxyethoxy (--O--CH.sub.2 CH.sub.2 OCH.sub.3) modification at the 2' position of at least one nucleotide. Methods of inhibiting PKC expression and methods of treating conditions associated with expression of PKC using oligonucleotides of the invention are disclosed.