The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 07, 1999
Filed:
Apr. 23, 1997
Applicant:
Inventors:
Lih-Ling Lin, Concord, MA (US);
Jennifer Chen, Chestnut Hill, MA (US);
Andrea R Schievella, Winchester, MA (US);
James Graham, Somerville, MA (US);
Assignee:
Genetics Institute, Inc., Cambridge, MA (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N / ; C12N / ; C12N / ; C07K / ;
U.S. Cl.
CPC ...
435 691 ; 536 231 ; 536 235 ; 4353201 ; 435325 ; 4352523 ; 43525411 ; 530350 ; 530351 ;
Abstract
Novel TNF receptor death domain ('TNF-R1-DD') ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.