The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 17, 1999
Filed:
Feb. 26, 1996
Applicant:
Inventors:
Lawrence Steinman, Palo Alto, CA (US);
Ari Waisman, Tel-Aviv, IL;
Assignee:
The Board of Trustees of The Leland Stanford Junior University, Palo Alto, CA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A01N / ; A61K / ; C12N / ; C12N / ;
U.S. Cl.
CPC ...
514 44 ; 435455 ; 4353201 ; 435 691 ; 800-9 ; 424-921 ;
Abstract
A pro-inflammatory T response is specifically prevented by the injection into a recipient of DNA encoding the variable region of a T cell receptor. In response to the vaccination, T cells expressing the variable region produce Th2 cytokines, including IL-4. A pro-inflammatory T cell response directed to an autoantigen is shown to be suppressed by DNA vaccination. The suppressive vaccination further reduced the inflammatory effect of T cells reactive against epitopes of the autoantigen not recognized by the variable region used for vaccination.