The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 17, 1999

Filed:

May. 08, 1997
Applicant:
Inventors:

Huo-shu H Houng, Burtonsville, MD (US);

Richard L Warren, Blue Bell, PA (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; A01N / ; C12P / ; C12P / ;
U.S. Cl.
CPC ...
4242521 ; 4242351 ; 4242341 ; 4241841 ; 424 931 ; 424 932 ; 435 41 ; 435 691 ; 4351723 ; 4352523 ; 4353201 ;
Abstract

The vaccines are prepared by isolating the Brucella genes complementing mutations in the purEK genes of Escherichia coli, physically mapping, determining the DNA sequence, constructing a defined deletion mutation by polynucleotide chain reaction (PCR), introducing a selectable marker into the deletion, and then selecting a purE mutant in Brucella arising by allelic exchange. The resulting Brucella require purines for growth because they lack the purE gene product that is required for the carboxylation of 5'-phosphoribosyl-5-aminoimidazole.


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Houng, Huo-shu. (1999). Mutants of brucella melitensis (U.S. Patent No. 5939075). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/5939075

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