The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 27, 1999
Filed:
Aug. 11, 1997
Applicant:
Inventors:
George W Muller, Bridgewater, NJ (US);
Mary Shire, North Plainfield, NJ (US);
Assignee:
Celgene Corporation, Warren, NJ (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; A61K / ; C07C / ; C07C / ; C07C / ; C07C / ; C07C / ; C07C / ;
U.S. Cl.
CPC ...
514576 ; 514520 ; 514532 ; 514538 ; 514584 ; 514585 ; 514613 ; 514617 ; 514619 ; 514622 ; 514630 ; 514631 ; 514646 ; 514678 ; 514679 ; 514764 ; 514784 ; 514785 ; 558401 ; 558402 ; 558410 ; 560 61 ; 560 64 ; 560 73 ; 562405 ; 562434 ; 562452 ; 562455 ; 562459 ; 562463 ; 562465 ; 562490 ; 564123 ; 564161 ; 564166 ; 564167 ; 564182 ; 568308 ; 585 24 ; 585 25 ; 546348 ; 5463461 ; 546579 ; 549 80 ; 549429 ; 5483461 ; 548579 ;
Abstract
Cyano and carboxy derivatives of substituted styrenes are inhibitors of tumor necrosis factor .alpha., nuclear factor .kappa.B, and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovirus replication, asthma, and inflammatory conditions. A typical embodiment is 3,3-bis-(3,4-dimethoxyphenyl)acrylonitrile.