The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 27, 1999
Filed:
Dec. 15, 1995
Thomas Brian McMurry, Killiney, IE;
Robert Stanley McElhinney, Delgany, IE;
Dorothy Josephine Donnelly, Dublin, IE;
Paul Murray, Nurney, IE;
Christophe Carola, St. Leu-la-Foret, FR;
Rhoderick Hugh Elder, Cheshire, GB;
Jane Kelly, Manchester, GB;
Geoffrey Paul Margison, Poynton, GB;
Joseph Anthony Rafferty, Stockport, GB;
Amanda Jean Watson, Cheshire, GB;
Mark Andrew Willington, Cheshire, GB;
Cancer Research Campaign Technology Limited, London, GB;
Abstract
The present invention provides certain 6-hetarylalkyloxy pyrimidine derivatives of formula II ##STR1## wherein R is (i) a cyclic group having at least one 5- or 6-membered heterocyclic ring, optionally with a carbocyclic or heterocyclic ring fused thereto, the or each heterocyclic ring having at least one hetero atom chosen from O, N, or S, or a substituted derivative thereof; or (ii) phenyl or a substituted derivative thereof, R.sup.2 is selected from H, C.sub.1 -C.sub.5 alkyl, halogen or NH.sub.2, R.sup.4 and R.sup.5 which are the same or different are selected from H, NH.sub.2 or NO.sub.n where n=1 or 2, or R.sup.4 and R.sup.5 together with the pyrimidine ring form a 5-or 6-membered ring structure containing one or more heterocyclic atoms, and pharmaceutically acceptable salts thereof, exhibit the ability to deplete O.sup.6 -alkylguanine-DNA alkyltransferase (ATase) activity.