The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 06, 1999
Filed:
Oct. 03, 1997
Applicant:
Inventors:
William H Pearson, Ann Arbor, MI (US);
Erik J Hembre, Ann Arbor, MI (US);
Assignee:
The Regents of the University of Michigan, Ann Arbor, MI (US);
Primary Examiner:
Int. Cl.
CPC ...
C07F / ; C07D / ; C07D / ;
U.S. Cl.
CPC ...
549214 ; 549320 ; 546183 ;
Abstract
(-)-Swainsonine may be prepared by (i) reacting a compound of formula (8): ##STR1## wherein OMs is methanesulfonyl with H.sub.2 in the presence of Pd(OH).sub.2 followed by NaOMe, to obtain a compound of formula (9): ##STR2## and (ii) reducing the carbonyl group and hydrolyzing the ketal group in the compound of formula (9) to obtain (-)-swainsonine of formula (1): ##STR3##