The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 06, 1999
Filed:
Nov. 21, 1997
Matthew S Platz, Columbus, OH (US);
Tongqian Chen, Fort Collins, CO (US);
Shashi S Kagan, Valley Cottage, NY (US);
Helena M Pereira, Aubervilliers, FR;
The Ohio State Research Foundation, Columbus, OH (US);
Abstract
The present invention relates to novel, halogenated psoralen compounds that are useful for inactivating vital contaminants in blood-derived products, particularly blood-derived products that contain platelets or red blood cells. The psoralen compounds of the present invention have the following formula: The side chain S which is a attached to the carbon at position 8 of the psoralen moiety contains a quartemary ammonium group which comprises a central nitrogen atom, a linking group L, and an aromatic ring structure. The linking group L joins the central nitrogen atom of the quartenary ammonium group to the psoralen moiety. The linking group L comprises a carbon chain having 2 to 12 carbon atoms and an oxygen atom which links the carbon chain to the psoralen moiety. The psoralen compounds of the present invention also comprise one or more halogens attached to the psoralen moiety. Preferably the halogens are attached to the carbon atom at position 3 or 5 of the psoralen moiety. In one class of these novel psoralen compounds, the central nitrogen atom of the quartenary ammonium group is a component of the aromatic ring structure. In another class, the central nitrogen atom is attached to three substituent groups, R.sup.1, R.sup.2, and R.sup.3 wherein R.sup.3 has the following structure: --R.sup.5 --CH.dbd.CH--R.sup.6 wherein R.sup.5 is a carbon chain comprising 1 to 3 carbon atoms, and wherein R.sup.6 is the aromatic ring, The present invention also relates to methods of making and using the novel psoralen compounds.