The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 06, 1999
Filed:
Oct. 28, 1997
Applicant:
Inventors:
Mark E Duggan, Schwenksville, PA (US);
George D Hartman, Lansdale, PA (US);
William F Hoffman, Lansdale, PA (US);
Nathan C Ihle, Mercer Island, WA (US);
Assignee:
Merck & Co., Inc., Rahway, NJ (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; A61K / ; A61K / ; A61K / ; A61K / ; C07D / ; C07D / ; C07D / ; C07D / ; C07D / ; C07D / ; C07D / ; C07D / ; C07D / ; C07D / ; C07D / ; C07D / ; C07D / ; C07D / ; C07D / ; C07D / ; C07D / ; C07D / ; C07D / ;
U.S. Cl.
CPC ...
514300 ; 514256 ; 514269 ; 514272 ; 514274 ; 514275 ; 514303 ; 514346 ; 514349 ; 514350 ; 514351 ; 514352 ; 514354 ; 514355 ; 514356 ; 514357 ; 514369 ; 514370 ; 514371 ; 514393 ; 514394 ; 514395 ; 514396 ; 514398 ; 514399 ; 514400 ; 514401 ; 514418 ; 514419 ; 544297 ; 544311 ; 544312 ; 544314 ; 544315 ; 544316 ; 544317 ; 544318 ; 544321 ; 544323 ; 544326 ; 544327 ; 544329 ; 544332 ; 544335 ; 546118 ; 546122 ; 546123 ; 546290 ; 546291 ; 546292 ; 546293 ; 546294 ; 546296 ; 546297 ; 546298 ; 546299 ; 546300 ; 546301 ; 546304 ; 546305 ; 546306 ; 546307 ; 546308 ; 546309 ; 546310 ; 546311 ; 546312 ; 546313 ; 546314 ; 546315 ; 546316 ; 546318 ; 546321 ; 546322 ; 546323 ; 546324 ; 546326 ; 546328 ; 546329 ; 546331 ; 546332 ; 546333 ; 546334 ; 546339 ; 546340 ; 548182 ; 548183 ; 548184 ; 548185 ; 548186 ; 548187 ; 548190 ; 548191 ; 548192 ; 548193 ; 548194 ; 548200 ; 548201 ; 548202 ; 548203 ; 548204 ; 5483027 ; 5483044 ; 5483064 ; 5483071 ; 5483074 ; 5483077 ; 5483081 ; 5483084 ; 5483087 ; 5483091 ; 5483097 ; 5483101 ; 5483164 ; 5483171 ; 5483191 ; 5483195 ; 5483215 ; 5483221 ; 5483225 ; 5483231 ; 5483235 ; 5483241 ; 5483265 ; 5483311 ; 5483315 ; 5483321 ; 5483325 ; 5483335 ; 5483341 ; 5483345 ; 5483351 ; 5483355 ; 5483094 ; 5483361 ; 5483365 ; 5483381 ; 5483401 ; 5483411 ; 5483415 ; 5483471 ; 5483491 ; 5483501 ;
Abstract
This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as vitronectin receptor antagonists. The vitronectin receptor antagonist compounds of the present invention are .alpha.v.beta.3 antagonists, .alpha.v.beta.5 antagonists or dual .alpha.v.beta.3/.alpha.v.beta.5 antagonists useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation and tumor growth.