The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 06, 1999
Filed:
Jun. 07, 1995
Applicant:
Inventors:
Anna Aldovini, Winchester, MA (US);
Richard A Young, Winchester, MA (US);
Mark B Feinberg, San Francisco, CA (US);
Didier Trono, Solana Beach, CA (US);
David Baltimore, New York, NY (US);
Assignee:
Whitehead Institute for Biomedical Research, Cambridge, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; C07K / ; C12N / ;
U.S. Cl.
CPC ...
4241881 ; 4242081 ; 435 691 ; 4352351 ; 435236 ; 530826 ;
Abstract
This invention related to constructs comprising mutant HIV genomes having an alteration in a nucleotide sequence which is critical for genomic RNA packaging and non-infectious, immunogenic HIV particles produced by expression of these constructs in mammalian cells. Cell lines which stably produce non-infectious, immunogenic HIV particles are also included. Prophylactic and therapeutic vaccines, diagnostic reagents, and related methods are further described.