The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 29, 1999
Filed:
Mar. 20, 1997
Christian P Larsen, Atlanta, GA (US);
Alejandro A Aruffo, Edmonds, WA (US);
Diane L Hollenbaugh, Seattle, WA (US);
Peter S Linsley, Seattle, WA (US);
Jeffrey A Ledbetter, Seattle, WA (US);
Thomas C Pearson, Atlanta, GA (US);
Bristol-Myers Squibb Company, Pinceton, NJ (US);
Emory University, Atlanta, GA (US);
Abstract
The present invention provides a method for inhibiting an immune reponse and a method for inhibiting rejection of transplanted tissues. This method comprises preventing an endogenous molecule on a cell selected from the group consisting of gp39 and CD40 antigens from binding its endogenous ligand and preventing an endogenous molecule on a cell selected from the group consisting of CTLA4, CD28, and B7 antigens from binding its endogenous ligand. The prevention of such molecules from binding their ligand thereby blocks two independent signal pathways and inhibits the immune response resulting in transplanted tissue rejection.