The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 22, 1999

Filed:

Feb. 12, 1997
Applicant:
Inventors:

Pamela Gehron Robey, Bethesda, MD (US);

Paolo Bianco, Rome, IT;

Sergei Kuznetsov, Bethesda, MD (US);

David Rowe, West Hartford, CT (US);

Paul Krebsbach, Bethesda, MD (US);

Mahesh H Mankani, Bethesda, MD (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61F / ; A01N / ; A61K / ; C12N / ;
U.S. Cl.
CPC ...
424423 ; 424422 ; 424426 ; 424489 ; 424 937 ; 435325 ; 435366 ; 435372 ; 435395 ;
Abstract

An in vivo model for human bone metabolism. Human marrow stromal fibroblasts are isolated, expanded in culture, combined with ceramic powder (hydroxyapatite) delivery vehicles with or without fibrin glue and implanted into a mammal. This protocol results in the formation of self-maintained human bone which supports hematopoiesis. This model system can be used to screen compounds which inhibit or stimulate bone formation. The marrow stromal fibroblast delivery vehicles can be implanted into humans to augment bone implants or to repair bone defects.


Find Patent Forward Citations

Robey, Pamela. (1999). Formation of human bone in vivo using ceramic powder and human marrow (U.S. Patent No. 5914121). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/5914121

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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