The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 15, 1999
Filed:
Mar. 20, 1997
Applicant:
Inventors:
Yuling Li, Germantown, MD (US);
Mark Oelkuct, Frederick, MD (US);
Reiner L Gentz, Silver Spring, MD (US);
Assignee:
Human Genome Sciences, Inc., Rockville, MD (US);
Primary Examiner:
Int. Cl.
CPC ...
C07K / ; C07K / ; C07K / ; C07K / ;
U.S. Cl.
CPC ...
530412 ; 530325 ; 530414 ; 530416 ; 530417 ; 530419 ; 530420 ; 435 695 ; 435 712 ; 435471 ; 4352523 ; 4353201 ;
Abstract
The present invention relates to processes for the purification of proteins. More specifically, methods for solubilizing and purifying proteins expressed in an insoluble form using low concentrations of chaotropic agents, such as guanidine salts, are provided. Also provided are methods for refolding proteins solubilized according to the present invention.