The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 25, 1999
Filed:
Jan. 27, 1998
Stephen John Pegg, Macclesfield, GB;
George Joseph Sependa, Macclesfield, GB;
Elwyn Peter Davies, Macclesfield, GB;
Chris Allan Veale, Newark, DE (US);
Zeneca Limited, , GB;
Abstract
The present invention relates to pyrrolidine derivatives, and more particularly to the compound (S)-1-�(S)-2-(4-methoxybenzamido)-3-methylbutyryl!-N-�(S)-2-methyl-1-(trif luoroacetyl)propyl!pyrrolidine-2-carboxamide, shown by formula I, and solvates thereof. The present invention also provides pharmaceutical compositions, intermediates and methods of preparation of the compound. The compound of formula I is an inhibitor of human neutrophil elastase and is useful in the treatment of diseases in which the enzyme is implicated, such as, for example, emphysema and acute respiratory distress syndrome (ARDS).