The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 18, 1999
Filed:
Aug. 06, 1997
Applicant:
Inventors:
Dinesh Gala, East Brunswick, NJ (US);
Ingrid Mergelsberg, Dagmersellen, CH;
Martin Steinman, Livingston, NJ (US);
Brigitte Giesinger, Lucerne, CH;
Dominik Scherer, Horw, CH;
Assignee:
Schering Corporation, Kenilworth, NJ (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D / ;
U.S. Cl.
CPC ...
544295 ; 544333 ; 544370 ; 5483355 ; 5483415 ; 5483425 ;
Abstract
Aminomethyl-phenylimidazoles are produced by reaction of an ester of a hydroxymethyl-phenylimidazole with an amine. A particularly preferred ester is the acetate ester. The aminomethyl-phenylimidazoles have useful properties as highly selective partial agonists or antagonists at brain dopamine receptor subtypes. A preferred compound prepared is 5-fluoro-2-�4-�(2-phenyl-1H-imidazol-5-yl)methyl!-1-piperazinyl!pyrimidine . Esters of the hydroxymethyl-phenylimidazoles are useful intermediates.