The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 18, 1999
Filed:
Jul. 08, 1997
Applicant:
Inventor:
Louis Brammer Hansen, V.ae butted.rl.o slashed.se, DK;
Assignee:
Novo Nordisk A/S, Novo Alle, Bagsvaerd, DK;
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ;
U.S. Cl.
CPC ...
530303 ; 530324 ; 530345 ; 530402 ; 514-3 ;
Abstract
A method of selectively acylating an insulin, an insulin analogue or a precursor thereof having a free .epsilon.-amino group of a Lys residue contained therein and at least one free .alpha.-amino group which method comprises reacting the .epsilon.-amino group with an activated amide in a polar solvent in the presence of a base.