The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 04, 1999
Filed:
Sep. 08, 1997
Applicant:
Inventors:
James M Clark, San Mateo, US;
Thomas E Jenkins, LaHonda, US;
Bradley A Katz, , US;
Robert M Stroud, both of San Francisco, all of, CA (US);
Assignees:
Axys Pharmaceuticals Inc., San Francisco, US;
The Regents of the University of California, Oakland, both of, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N / ; C12N / ; C12N / ;
U.S. Cl.
CPC ...
435184 ; 435180 ; 435183 ; 435213 ; 514184 ;
Abstract
Serine protease inhibitors are provided comprising compounds having a P site binding moiety and a divalent cation(s) chelating moiety which are pre-prepared as divalent cation(s) complexes or combined with the serine protease in the presence of divalent cation(s). The compounds are shown to have high inhibitory activity when complexed to divalent cation(s) and find use in various processes associated with serine protease isolation and inhibition.