The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 06, 1999

Filed:

May. 09, 1995
Applicant:
Inventors:

Susan Mancini Cady, Yardley, PA (US);

John Steele Logan, Robbinsville, NJ (US);

Brian Lee Buckwalter, Yardley, PA (US);

Gerald William Stockton, Yardley, PA (US);

Deborah Tardy Chaleff, Pennington, NJ (US);

Assignee:

American Cyanamid Company, Wayne, NJ (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; C07K / ;
U.S. Cl.
CPC ...
514-2 ; 514 21 ; 530399 ; 424423 ;
Abstract

Novel modified or derivatized recombinant animal somatotropins. Methods for stabilizing recombinant animal somatotropins by modification or deletion of the Cysteine residues utilizing site directed mutagenesis to replace from one to four of the cysteine amino acid residues of said somatotropins with one or more different amino acid residues or by derivatization of (1) both cysteine amino acid residues in the small loop of said somatotropin, both cysteine amino acid residues in the large loop or the four cysteine amino acid residues in both loops of said somatotropin.


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