The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 06, 1999
Filed:
Jan. 20, 1998
Applicant:
Inventors:
Thomas D Gaffney, Chapel Hill, NC (US);
Stephen T Lam, Raleigh, NC (US);
Assignee:
Novartis Finance Corporation, New York, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K / ; C12N / ; C12N / ; C12N / ;
U.S. Cl.
CPC ...
4351723 ; 4352523 ; 43525234 ; 4353201 ; 530350 ; 536 237 ;
Abstract
The present invention exploits the discovery that certain single base changes in the gacA gene coding sequence, which result in certain single amino acid changes in the encoded GacA protein, render it LemA-independent. The present invention therefore provides DNA that encodes mutant GacA proteins that do not require phosphorylation by LemA in order to be active as transcriptional activators.