The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 06, 1999
Filed:
Mar. 23, 1995
Applicant:
Inventors:
Peter H Krammer, Heidelberg, DE;
Klaus-Michael Debatin, Heidelberg, DE;
Bernhard C Trauth, Mannheim, DE;
Iris Behrmann, Heidelberg, DE;
Jens Dhein, Edingen-Nhsn, DE;
Christiane Klas, Lorrach, DE;
Peter Moller, Heidelberg, DE;
Werner Falk, Schonhofen/Nittendorf, DE;
Alexander Oehm, Wiesbaden, DE;
Peter T Daniel, Reutlingen, DE;
Assignee:
Centocor, Inc., Malvern, PA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; A61K / ; C12P / ; C07K / ;
U.S. Cl.
CPC ...
4241431 ; 435 7021 ; 4351722 ; 43524027 ; 4341521 ; 4341531 ; 4341541 ; 4341551 ; 4341561 ; 4341721 ; 4341731 ; 4341741 ; 4342771 ; 5303871 ; 5303873 ; 53038875 ; 5303888 ; 53038885 ; 5303897 ;
Abstract
The APO-1 cellular membrane antigen, an about 50 kDa antigen associated with cellular apoptosis, and purified cDNA encoding same is described. The antigen is expressed by numerous normal and malignant cells, including activated and malignant lymphoid cells. Also disclosed are antibodies which bind the antigen, and which induce growth inhibition and apoptosis.