The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 30, 1999
Filed:
Mar. 31, 1997
Applicant:
Inventors:
Mark A Perrella, Brookline, MA (US);
Mu-En Lee, Newton, MA (US);
Assignee:
President and Fellows of Harvard College, Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; A61K / ; C12Q / ; C12Q / ;
U.S. Cl.
CPC ...
514 44 ; 424450 ;
Abstract
The invention features a method of inhibiting sepsis-associated hypotension in a mammal which includes the steps of identifying a mammal suffering from or at risk of developing sepsis and administering to the mammal a compound which inhibits expression of inducible heme oxygenase (HO-1). Also disclosed are screening assays useful for identifying a compound capable of inhibiting HO-1 expression or enzymatic activity.