The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 30, 1999
Filed:
Dec. 30, 1994
Hidesaburo Hanafusa, New York, NY (US);
Beatrice S Knudsen, New York, NY (US);
Stephan M Feller, New York, NY (US);
John Kuriyan, New York, NY (US);
Xiaodong Wu, New York, NY (US);
Jie Zheng, New York, NY (US);
David Cowburn, Westfield, NJ (US);
The Rockefeller University, New York, NY (US);
Abstract
The present invention relates to regulation and control of cellular processes by SH3-domain binding proteins and peptides. In particular, the invention provides a consensus sequence of a peptide that shows high specificity and affinity for the first SH3 domain of cellular Crk. In specific examples, a number of peptides that contain the consensus are shown to bind c-Crk specifically. The molecular basis for this specificity is examined by crystallography.