The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 30, 1999

Filed:

Jun. 07, 1995
Applicant:
Inventors:

James G Bender, Lindenhurst, IL (US);

Phillip B Maples, Waukegan, IL (US);

Stephen Smith, Arlington Heights, IL (US);

Kristen L Unverzagt, Palatine, IL (US);

Dennis E Van Epps, Cary, IL (US);

Assignee:

Nexell Therapeutics Inc., Irvine, CA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; A61K / ; C12N / ; C12N / ;
U.S. Cl.
CPC ...
424 931 ; 424520 ; 424577 ; 424 933 ; 424 937 ; 424 9321 ; 435325 ; 435326 ; 435366 ; 435372 ; 4351723 ; 435 691 ; 514 44 ;
Abstract

A suspension comprising human neutrophil precursor cells, wherein the cellular component is comprised of at least about 16% human myeloblasts and promyeclocytes, which have been derived from neutrophis progenitor cells obtained from peripheral blood, bone marrow or cord blood, and less than about 5% colony forming units (CFU) of at least about 50 cells is provided. An alternative suspension comprising human neutrophil precursor cells, wherein the cellular component is comprised of at least about 16% CD15+CD11b- cells and less than about 5% colony forming units (CFU) of at least about 50 cells also is provided, wherein at least about 60% of the CD15+CD11b- cells are myeloblasts and promyelocytes. The suspensions of the invention are useful in methods for increasing neutrophil populations in a patient having a reduced populations of neutrophils.


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