The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 23, 1999
Filed:
Jan. 19, 1996
Applicant:
Inventors:
Ralph F Hirschmann, Blue Bell, PA (US);
Amos B Smith, III, Merion, PA (US);
Paul Sprengeler, Philadelphia, PA (US);
Wenqing Yao, Lansdowne, PA (US);
Paul Anderson, Lansdale, PA (US);
Assignee:
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; C07C / ;
U.S. Cl.
CPC ...
514617 ; 514375 ; 514407 ; 514485 ; 514619 ; 514620 ; 514621 ; 514622 ; 548218 ; 5483751 ; 560 27 ; 564155 ; 564156 ; 564165 ; 564169 ; 564174 ;
Abstract
This invention relates to chemical compounds that contain adjacent carbonyl groups, which effectively inhibit the biological, chemical, and/or physical properties of enzymes and other medicinally-significant proteins. In particular, the invention relates to dicarbonyl compounds that are capable of acting as enzyme inhibitors, including irreversible inhibitors of HIV-1 protease.