The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 23, 1999

Filed:

May. 30, 1997
Applicant:
Inventors:

Harold Clinton Kluender, Trumbull, CT (US);

Brian Richard Dixon, Woodbridge, CT (US);

Michael Christopher VanZandt, Guilford, CT (US);

Scott McClelland Wilhelm, Orange, CT (US);

Donald John Wolanin, Orange, CT (US);

William Harrison Bullock, West Haven, CT (US);

Assignee:

Bayer Corporation, Pittsburgh, PA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; A61K / ; C07C / ; C07C / ;
U.S. Cl.
CPC ...
514568 ; 514545 ; 514423 ; 514616 ; 562459 ; 560 51 ; 548536 ; 548537 ; 564155 ; 564158 ;
Abstract

Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula ##STR1## wherein each T is a substituent group; x is 0, 1, or 2; the group D represents ##STR2## the group R6 represents variety of possible substituent groups on the carbon chain between D and G, and the group G represents M, ##STR3## in which M represents --CO.sub.2 H, --CON(R.sup.11).sub.2, or --CO.sub.2 R.sup.12, and R.sup.13 represents any of the side chains of the 19 noncyclic naturally occurring amino acids.


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