The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 16, 1999

Filed:

Apr. 04, 1994
Applicant:
Inventors:

Annemarie Veenstra, Nieuw Vennep, NL;

Juan Francisco Martin, Leon, ES;

Bruno Diez Garcia, San Sebastian, ES;

Santiago Gutierez, Leon, ES;

Jose Luis Barredo, Burgos, ES;

Eduardo Montenegro Prieto, Leon, ES;

Hans Von Doehren, Berlin, DE;

Harriet Palissa, Berlin, DE;

Henk Van Liempt, Berlin, DE;

Assignee:

Gist-Brocades, N.V., Delft, NL;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12P / ; C12N / ;
U.S. Cl.
CPC ...
435 43 ; 435 691 ; 4352523 ; 43525233 ; 43525235 ; 4352543 ; 43525411 ; 4353201 ; 4352545 ; 536 232 ;
Abstract

Novel methods and compositions are provided for the enhanced production of .beta.-lactam antibiotics. The process is exemplified by the production of penicillin. In addition, the P. chrysogenum and A. chrysogenum .delta.-(L-.alpha.-aminoadipyl)-L-cysteinyl-D-valine synthetase genes have been isolated and sequenced. Also methods are provided for the production of .delta.-(L-.alpha.-aminoadipyl)-L-cysteinyl-D-valine synthetase using recombined DNA techniques.


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