The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 09, 1999
Filed:
Jul. 22, 1997
Bernhard Fischer, Vienna, AT;
Artur Mitterer, Orth/Donau, AT;
Friedrich Dorner, Vienna, AT;
Hans-Peter Schwarz, Vienna, AT;
Peter Turecek, Vienna, AT;
Johann Eibl, Vienna, AT;
Falko-Guenter Falkner, Orth/Donau, AT;
Uwe Schlokat, Orth/Donau, AT;
Wolfgang Mundt, Vienna, AT;
Manfred Reiter, Vienna, AT;
Renate Den-Bouwmeester, Vienna, AT;
Immuno Aktiengesellschaft, Vienna, AT;
Abstract
The invention relates to a method for isolation of highly pure von Willebrand Factor in which recombinant von Willebrand Factor (rvWF) is chromatographically purified by anion exchange chromatography on an anion exchanger of the quaternary amino type in a buffer solution comprising buffer substances and optionally salt. The buffer solutions are preferably free of stabilizers, amino acids and other additives. According to this method, highly pure recombinant vWF can be obtained, which is free from blood plasma proteins, especially free from Factor VIII, and is physiologically active. Further, the invention relates to a pharmaceutical preparation that contains rvWF, which is comprised of multimers with a high structural integrity.