The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 09, 1999
Filed:
Aug. 12, 1997
Ryo Muramatsu, Toda, JP;
Akiko Sukesada, Toda, JP;
Satoru Misawa, Toda, JP;
Eriko Nukui, Takoaki, JP;
Koichi Wada, Takaoka, JP;
Masaharu Nakano, Takaoka, JP;
Tadanori Morikawa, Takaoka, JP;
Kyoichi Kobashi, Toyama, JP;
Japan Energy Corporation, Tokyo, JP;
Fuji Yakuhin Kogyo Kabushiki Kaisha, Toyama, JP;
Abstract
The present invention relates to hirudin variants having high anti-thrombin and anti-platelet activity, methods for producing them, and anti-coagulants having said variants as active ingredients. Hirudin variants shown in formula (I) having tyrosine residues or having their hydroxyl group sulfated. Methods for producing hirudin variants by sulfating hydroxyl group of said tyrosine residues, and anti-coagulants having hirudin variants shown in formula (I) as active ingredients.