The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 02, 1999
Filed:
Oct. 02, 1997
Applicant:
Inventor:
Karel M Brands, Hoboken, NJ (US);
Assignee:
Merck & Co., Inc., Rahway, NJ (US);
Primary Examiner:
Int. Cl.
CPC ...
C07D / ;
U.S. Cl.
CPC ...
548412 ;
Abstract
A process for the synthesis of an N-(di-substituted phosphoryl)-trans-4-hydroxy-L-proline of the formula I: ##STR1## is disclosed, wherein R.sup.1 and R.sup.2 independently represent C.sub.1-18 alkyl, phenyl or phenyl-substituted C.sub.1-18 alkyl, or R.sup.1 and R.sup.2 are taken in combination to represent C.sub.2-4 alkylidene or phenyl. Trans-4-hydroxy-L-proline is reacted with a di-(substituted) phosphite of the formula III: ##STR2## in the presence of sodium hypochlorite and sodium hydroxide to produce a compound of formula I.