The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 02, 1999
Filed:
Jun. 15, 1998
Applicant:
Inventors:
Alan R Shuldiner, Columbia, MD (US);
Jeremy Walston, Baltimore, MD (US);
Kristi Silver, Baltimore, MD (US);
Jesse Roth, Baltimore, MD (US);
Assignee:
The Johns Hopkins University School of Medicine, Baltimore, MD (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K / ;
U.S. Cl.
CPC ...
530350 ; 530395 ; 530827 ; 536 235 ;
Abstract
The present invention provides a novel polypeptide characterized by a non-conservative missense mutation, Trp64Arg, in the .beta.3-adrenergic receptor (.beta.3AR) that increases susceptibility to obesity and non-insulin dependent diabetes mellitus (NIDDM; type II diabetes). Also provided are methods of diagnosis and methods of treatment of subjects having or at risk of having type II diabetes/obesity.