The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 02, 1999

Filed:

Jun. 06, 1995
Applicant:
Inventor:

James G Wetmur, Scarsdale, NY (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K / ; C12Q / ; G01N / ; G01N / ;
U.S. Cl.
CPC ...
530350 ; 435-6 ; 435 911 ; 436501 ; 436 94 ;
Abstract

Isolated nucleic acids which encode a thermostable protein which binds specifically to bulge loops in a heteroduplex nucleic acid and recombinant vectors comprising nucleic acid which encodes a thermostable protein which binds specifically to bulge loops in a heteroduplex nucleic acid are disclosed. Also disclosed are isolated thermostable proteins which bind specifically to bulge loops in a heteroduplex nucleic acid and host cells comprising a recombinant gene which can express a thermostable protein which binds specifically to bulge loops in a heteroduplex nucleic acid. Further disclosed are a method of reducing DNA misincorporation in an amplification reaction, methods for detecting a nucleic acid which includes a specific sequence, a method for amplifying a nucleic acid comprising a specific sequence, and a method for selecting against a nucleic acid comprising a specific sequence.


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