The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 02, 1999

Filed:

Nov. 22, 1996
Applicant:
Inventors:

Malcolm A O'Neill, Winterville, GA (US);

Patrice J Pellerin, Montpellier, FR;

Dennis Warrenfeltz, Athens, GA (US);

Stephane Vidal, Combaillaux, FR;

Alan G Darvill, Athens, GA (US);

Peter Albersheim, Athens, GA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; C07H / ; G01N / ;
U.S. Cl.
CPC ...
514 54 ; 514 64 ; 536-2 ; 536123 ; 5361231 ; 436 79 ; 436 82 ;
Abstract

The present invention provides rhamnogalacturonan-II (RG-II) and relates to its ability to complex specific multivalent heavy metal cations. In the presence of boric acid, RG-II monomers form dimers that are cross-linked by a borate ester. The yield of such borate ester cross-linked dimers of RG-II is enhanced in the presence of specific heavy metal cations. The present invention further relates to the utility of RG-II in assays for the detection of specific heavy metal contamination; as a reagent useful in the removal of specific heavy metal cations contaminating foods and liquids, for example, fish, wines, etc.; as a pharmaceutical composition useful as an antidote in specific heavy metal cation poisoning; as a treatment for the detoxification of specific heavy metal cations from blood and/or tissues; and in a method of remediation of waters and soils contaminated with specific heavy metal cations.


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