The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 16, 1999
Filed:
Jun. 30, 1995
Kyle R Gee, Springfield, OR (US);
Hon Cheung Lee, Woodbury, MN (US);
Robert Aarhus, Brooklyn Park, MN (US);
Richard P Haugland, Eugene, OR (US);
Timothy F Walseth, Roseville, MN (US);
Richard M Graeff, St. Paul, MN (US);
Molecular Probes, Inc., Eugene, OR (US);
The Regents of the University of Minnesota, Minneapolis, MN (US);
Abstract
The present invention describes a family of photolabile caged nucleotides, including cyclic nucleotides. The compounds of the present invention are caged analogs and derivatives of NAD.sup.+, NADH, NADP, NADPH, NAADP and cADPR. The photolysis of the present compounds allows the release of the free nucleotide in vivo or in vitro with precise spatial and temporal control. The compounds are useful for the photolytic generation of free nucleotides in aqueous samples, for example, in the study of calcium mobilization in cells and cell homogenates.